1PARIS A, TONNER P H. Dexmedetomidine in anaesthesia [ J ]. Curr Opin Anaesthesiol,2005, 18 ( 3 ) :412-418.
2GUO T Z, JIANG J Y, BUTFERMANN A E, et al. Dexmedetomidine injection into the locus eeruleus produces antinociception [ J ]. Anesthesiology, 1996, 84 ( 7 ) : 873 - 881.
3NELSON L E, LU J, GUO T, et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects [ J ]. Anesthesiology, 2003,98 ( 3 ) :428-436.
4NACIF-COELHO C, CORREA-SALES C, CHANG L L, et al. Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat [ J ]. Anesthesiology, 1994, 81 (10) : 1527-1534.
5EISENACH J C, SHAFER S L, BUCKLIN B A, et al. Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep [ J ]. Anesthesiology, 1994, 80 (9) :1349-1359.
6VENN R M, BRADSHAW C J, SPENCER R, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit [ J ]. Anaesthesia, 1999,54 ( 8 ) : 1136-1142.
7CORTINEZ L I, HSU Y W, SUM-PING S T, et al. Dexmedetomidine pharmacodynamics, part II : crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers [ J ]. Anesthesiology, 2004,101 (7) :1077-1083.
8HOFFMAN W E, KOCHS E, WERNER C, et al. Dexmedetomidine improves neurologic outcome from incomplete isehemia in the rat: reversal by the alpha 2-adrenergic antagonist atipamezole [ J ]. Anesthesiology, 1991,75 ( 2 ) : 328 -332.
9ZORNOW M H, FLEISCHER J E, SCHELLER M S, et al. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anestbetized dog [J]. Artesth Analg,1990,70(5) :624-630.
10DRUMMOND J C, DAO A V, ROTH D M, et al. Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans [J], Anesthesiology,2008,108(2) :225-232.
