鲍曼不动杆菌468株的临床分布及耐药性研究

Analysis of clinical distribution and drug resistance in 468 strains of acinetobacter baumannii

目的了解鲍曼不动杆菌的临床分布及耐药性,为临床合理用药提供实验室依据。方法回顾性分析山西省太原市某医院2009年1月至12月临床分离的非重复鲍曼不动杆菌的临床分布及耐药性。结果 2009年共分离鲍曼不动杆菌468株,主要分布在呼吸科及重症监护病房(ICU),来自痰标本76.3%,其他标本23.7%。米诺环素的耐药率最低(13.4%),其次是头孢哌酮/舒巴坦29.0%、亚胺培南31.2%、美罗培南31.8%、左氧氟沙星46.6%、阿米卡星49.0%,对其他的10种抗生素耐药率达50%以上。结论鲍曼不动杆菌多重耐药及泛耐药现象严重。通过对鲍曼不动杆菌的耐药率监测有助于临床合理选择抗菌药物,降低多重耐药株及泛耐药株的产生,并有效控制院内感染。

Objective To investigate the clinical distribution and drug resistance of acinetobacter baumannii（A.baumannii） in order to provide lab evidence of clinical rational administration.Methods A.baumannii isolated from different clinical specimens during the period of January to December in 2009 in one hospital in Taiyuan were retrospec-tively analyzed.Results The A.baumannii（468 strains totally isolated） were mainly distributed in pneumology depart-ment and intensive care unit（ICU）,76.3% were mainly isolated from sputum,23.7% from other specimens.The resistance rate to minocycline（13.4%） was the lowest in the 16 kinds of antibiotics,and the resistance rate to cefoper-azone-sulbactam,impenem,meropnem,levoflxacin and amikacin were 29.0%,31.2%,31.8%,46.6% and 49.0%,res-pectively,and the resistance rates to other 10 antibiotics were higher than 50%.Conclusion Drug resistant of A.baumannii was multiple and wide.Monitoring to resistant rate of A.baumannii was very helpful to administrate reasonably,reduce the multiple and wide resistance strains,and to control hospital infection of A.baumannii efficiently.