红细胞CR_1免疫粘附活性在急慢性乙肝病程发展中的作用

Significant Role of Immune adherence of Erythrocytes CR_1 in Pathogenicity of Acute and Chronic Hepatitis B

目的：研究红细胞CR1分子免疫粘附活性在急、慢性乙肝病程发展中的意义。方法：采用红细胞CR1免疫粘附功能试验，测定急、慢性乙型肝炎患者红细胞C3b受体花环(E-C3bRR)及免疫复合物（E－ICR）。结果：与正常对照组比较，急、慢性乙肝患者都不同程度地出现E－C3bRR下降及E－ICR升高的现象；急性乙肝患者在急性期，其红细胞CR1免疫粘附功能明显下降，于恢复期基本恢复正常；轻、中度慢性乙肝患者的肝功能正常与否，对其红细胞CR1免疫粘附活性有明显影响（P＜0．01）；重度慢性乙肝患者其红细胞CR1免疫粘附功能下降最明显。结论：急、慢性乙型肝炎患者其红细胞CR1免疫粘附功能状况与其发病机制及预后有明显相关性（R=0．8546），值得进一步深入研究。

Objective: To study the relationship between the immune - adherence of complement C3b receptortype I in erythrocytes and the pathogenicity of hepatitis B. Methods: Erythrocytes C3b receptor rosette (E - C3bRR) and erythrocytes immune complexes rosette (E - ICR) were measured in 78 cases of hepatitis B. Results:The results showed that the E - C3bRR of acute hepatites B in acute period was significantly lower,while the E- ICR was much higher, than that of control' s(P < 0. 01 ) and returned to normal level at convalescence. Thesituation of the liver function effected the ability of the immuneadherence of CR1 of erythrocytes obviously inhepatitis B,The E - C3bRR decreased significantly, while E Ai ICR increased, in chronic hepatitis B from lightdegree to middle and high degree(P< 0. 01 ). Concluslon: This study indicates that the ability of immune adhe rence of erythrocytes of hepatitis B was closely related to the developing of the diseases pathogenicity and it'sprognosis, It is worthy of studying further if clinic.