肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义

Serum levels of extracellular matrix protein 1,MMP-9 and VEGF in patients with hepatocellular carcinoma

目的检测肝细胞癌患者血清ECM1水平,分析其与MMP-9和VEGF水平间的关系。方法应用酶联免疫吸附法测定40例肝癌患者血清ECM1、MMP-9和VEGF水平,分析其与肿瘤临床与病理特征间的关系。结果 40例肝癌患者血清ECM1、MMP-9和VEGF平均水平分别为150.01±5.85pg/ml、467±30.81μg/l和751.29±51.08pg/ml;三者水平均与肿瘤包膜、TNM分级、发生淋巴结转移和肿瘤分期有关(P<0.005),而ECM1和VEGF还与血管侵犯有关(P<0.005);ECM1与MMP-9和VEGF水平呈显著正相关(r=0.438,P=0.005r;=0.427,P=0.006)。结论 ECM1可能通过与MMP-9和VEGF相互作用而促进了肝癌血管生成和侵袭转移。

Objective To investigate the serum levels of extracellular matrix protein 1（ECM1）,matrix metalloproteinase-9（MMP-9）and vascular endothelial growth factor（VEGF）in patients with HCC.Methods Serum levels of ECM1,MMP-9 and VEGF were detected by enzyme-linked immunosorbent assay in 40 patients with HCC.Results The serum ECM1,MMP-9 and VEGF levels were 150.01±5.85pg/ml,467±30.81μg/l and 751.29±51.08pg/ml;The serum levels of them were significantly associated with tumor capsula,TNM stage,lymph metastasis and Edmondson grade;ECM1 levels was positively correlated with MMP-9 and VEGF levels（r=0.438,P=0.005;r=0.427,P=0.006）.Conclusion ECM1 may stimulate angiogenesis,metastasis and invasion of HCC via interaction with MMP-9 and VEGF.