辛伐他丁治疗老Ⅱ型糖尿病脂代谢紊乱的疗效

The clinical efficacy of simvastatin in treating lipid metabolic disorder in the senile type-II diabetes

目的:探讨辛伐他丁对老年Ⅱ型糖尿病脂代谢紊乱患者的疗效.方法:30例老年Ⅱ型糖尿病脂代谢紊乱患者予辛伐他丁片5～20mgqn,用药4wk.结果:辛伐他丁降低TC25%,LDL-C降低25%,降低TG22.8%.对HDL-C降低者有升高作用,且降低TC/HDL-C21.8%,也降低载脂蛋白B18%.对血糖水平无不良影响.结论:辛伐他丁用于老年Ⅱ型糖尿病脂代谢异常患者安全、有效.

AIM:To know the curative efficacy of treating the senile type- I diabetic lipid metabolic disorder with HMG-CoA reducing enzyme depressor simvastatin. METHODS: Thirty patients of senile type-I diabetics lipid metabolic disorder toke simvastatin 5-20 mg/d in evening for 4 wk. RESULTS:Simvastatin reduced serum cholesterol 25%,reduced low densty lipoprotein 25%, reduced triglyceride 22. 8%,rosed high density lipoprotein(< 0.9 mmol/L), and reduced TC/HDL-C 21. 8%, reduced apolipoprotein B 18%,too. It had no effect on blood sugar. CONCLUSION:Simvastatin is one of the safty and effective drugs to treat the senile type- I diabetics lipid metabolic disorder