门脉高压症患者胃粘膜微循环障碍与血清中TNF、ET浓度变化的相关性

Relationship between Obstruction of Gastric Mucosal Microcir culation and Concentration of Serum TNF and ET in Patients with Protal Hypertension

目的：研究门脉高压性胃粘膜病变（ＰＨＧ）的实质及其与血清中ＴＮＦ、ＥＴ的浓度变化的关系。方法：对３０例门脉高压性胃粘膜病变患者和１５例门脉高压症非胃粘膜病变（ＮＰＨＧ）患者的胃粘膜进行光镜、透射电镜观察，同时应用放免法检测二组血清中ＴＮＦ、ＥＴ的浓度。结果：门脉高压时胃粘膜微循环障碍是ＰＨＧ形成的实质；门脉高压病患者血清中ＴＮＦ、ＥＴ的浓度变化与ＰＨＧ的发生、发展呈正相关；比较二组血清中ＴＮＦ、ＥＴ浓度差异有显著性（Ｐ＜０．０１）。结论：门脉高压时胃粘膜微循环变化包括有细胞机制和免疫反应二个方面的参与。

Objective: To study the characteristics of PHG and the relations with serum TNF and ET. Methods: 30 cases gastric mucosal of PHG and 15 cases gastric mucosal of NPHG were studied using light microscope and transmisson electron microscope, meanwhile to contrast with the two groups of concentration of serum TNF and ET by ELISA. Results: The obvious microcirculation obstruction of gastric mucosal during protal hypertension(PH) is the characteristics of PHG. Concentration change of serum TNF and ET is associated with the development of PHG. There are significant difference in serum TNF and ET between the two groups( P < 0.01 ). Conclusion: These observation suggest that the changes of gastric microcirculation during PH contain cell mechanism and immune status response.