血小板功能变化在血栓性疾病中的诊断意义

Diagnosis Valum of Platelet Function Changes in Thrombotic Disease

分别检测５种血栓性疾病（高血压、心绞痛、急性心肌梗塞、脑梗塞和糖尿病）的血小板粘附、血小板聚集、血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）以及全血、血浆粘度等指标。结果显示：上述５种疾病的血小板功能均有不同程度和类型变化。所有检测项目中变化最明显的是β－ＴＧ和血小板粘附性，其次为ＰＦ４和ＴＸＢ２，再次为血小板聚集性和６－ｋｅｔｏ－ＰＧＦ１α。这一发现有助于医师评估上述试验价值以及根据实验条件选择敏感试验。

Five thrombotic diseases, included: hypertension, agina pectoris, acute myocardial infarction, diabetes mellitus and cerebral infarction were investigated by platelet adhesive, platelet aggregation, Betathromoglobin(β TG), platelet factor 4(PF4), thromboxane B 2(TXB 2), 6 keto prostaglandin(6 keto PGF 1α ), as well as whole blood and plasma viscosity. The results showed that these diseases had similar platelet function changes. The most prominent or the most sensitive changes were β TG and platelet adhesive, the next were PF4 and TXB 2, and then platelet aggregation and 6 keto PGF 1α . The regularity will help the physician to estimate the various function tests and to select the related tests according to the lab conditions availible.