新兵人群幽门螺杆菌抗体水平回顾性血清流行病学调查

A retrospective seroepidemiology study of helicobacter pylori antibody level in the population of recruits

目的了解入伍新兵人群中幽门螺杆菌(helicobacter pylori,HP)IgG抗体的流行分布情况,为今后预防HP感染及其引发的相关胃部疾病提供科学依据。方法采用血清流行病学调查方法,利用酶联免疫吸附试验(ELISA)技术,对北京军区空军近8年来自16个省市的364名入伍新兵血清进行HP IgG抗体检测并进行统计分析。结果发现各年间入伍新兵血清HP IgG抗体水平阳性检出率为26.09%～77.27%,差异无统计学意义;福建、湖南、河北等地区HP IgG抗体阳性检出率较高,而山东、四川、黑龙江较低,地区间差异有统计学意义;沿海(54.40%)与内陆(39.56%)地区差异有统计学意义;入伍前是否集体生活,抗体阳性检出率差异无统计学意义。结论入伍新兵人群中HP IgG抗体阳性率为26.09%～77.27%,平均46.98%,具有地区差异。因此在新兵入伍期间,应加强饮食卫生、进行健康教育等有效措施预防。

Objective This study was conducted to investigate the distribution of helicobacter pylori（HP） antibody IgG in recruits,so as to provide scientific evidence for further prevention and control of the disease.Methods A seroepidemiological study was conducted by using Enzyme-Linked Immuno Sorbent Assay（ELISA）,serum samples of 364 recruits,who came from 16 provinces during the past eight years,were tested to detect HP antibody IgG and the overall positive rate was analysed statistically.Results There was no significant difference in serum HP antibody IgG levels among each year,which ranged from 26.09% to 77.27% with an average rate of 46.98%;regional differences was observed,the higher level was found in recruits from Fujian（77.27%）,Hunan（63.64%）,Hebei（63.64%）,Zhejiang（60.87%） and Jiangsu（60.87%）,and lower level from Shandong（26.09%）,Sichuan（26.09%） and Heilongjiang（30.43%）.There was no significant correlation between the antibody IgG positive rate and the collective life history before their recruitment.There was significant difference in serum HP antibody IgG levels between coastal（54.40%） and inland（39.56%）.Conclusions The positive rate of HP antibody IgG is not increasing year after year in the recuits,which ranges from 26.09% to 77.27%.The positive rate for antibody IgG varied significantly among different provinces.Strengthening food and drink hygine should be necessary for the recruits to prevent HP spreading.