母亲乙肝病毒感染与子代性别关系的回顾性调查

Retrospective study on the association between mothers HBV infection and offspring sex ratio

目的分析并探讨母亲乙型肝炎病毒感染与子代性别的关系。方法对哈尔滨市南岗区和道外区2000年1月~2005年12月所有有接生能力医院的产妇病案进行回顾性调查。调查内容包括：产妇基本情况,分娩时情况,新生儿情况。结果共调查18 935名母亲。其中HBsAg正常组18 085例,共娩出9 532名男婴和8 553名女婴,出生性别比为111.45。HBsAg携带组850例,娩出437名男婴和413名女婴,子代性别比为105.81。HBsAg携带组与正常组子代性别差异无统计学意义（χ2=0.546,P=0.46）。结论母亲HBsAg感染对子代性别无影响。

Objective To explore and analyze the association between the hepatitis B virus infection in mothers and the sex ratio of offspring.Methods Retrospective method was used to record the medical record of obstetrics in the total hospitals of Nangang and Daowai districts of Harbin from January 2000 to December 2005.Investigation included： the basic situation of maternal,delivery conditions,newborns.Results 18 935 mothers were investigated.18 085 mothers were negative for hepatitis B surface antigen,had 9 532 baby boys and 8 553 girls,the sex ratio at birth was 111.45.850 mothers were positive for hepatitis B surface antigen,and 437 baby boys and 413 girls,the sex ratio at birth was 105.81.The sex ratio between HBsAg carrier and non-carrier group had no statistical significance（χ2=0.546,P=0.46）.Conclusions No significant association was observed between HBsAg carrier and the sex ratio of offspring in this study.