血管内皮细胞、血浆内皮素值与糖尿病患者微血管病变的相关性及评估

Relationship between circulating endothelial cell number, plasma endothelin level and diabetic microangiopathy

目的 探讨糖尿病（ＤＭ）患者血管内皮细胞损伤及功能变化在微血管病变中的作用。方法 测定６０例ＤＭ患者及３０例正常人外周血循环内皮细胞（ＣＥＣ）数和血浆内皮素（ＥＴ）水平。结果 ＤＭ 患者ＣＥＣ数和ＥＴ水平明显高于正常人，其中伴微血管病变者增高更明显。两者均与糖化血红蛋白水平呈显著正相关。结论 两者共同参与糖尿病微血管病变的发生发展。

Objective To investigate the effect of the damage and functional change of vascular endothelial cells (VEC) on diabetic microangiopathy. Methods The number of circulating endothelial cells(CEC) and level of endothelin(ET) were measured in 30 normal subjects and 60 cases with diabetic mellitus (DM). Results The CEC number and ET level in diabetic patients were significantly higher than those in normal subjects; the CEC number and ET level in diabetic patients with microangiopathy were significantly higher than in those without microangiopathy. There was significant positive correlation between CEC number, ET level and HbA 1C level. Conclusion VEC damage and elevated plasma ET level may participate in the pathogenesis of diabetic microangiopathy synergistically.