三种疗法治疗慢性荨麻疹的疗效观察

Comparison on curative effects of three methods for chronic urticaria treatment

目的 探讨三种不同方法治疗慢性荨麻疹的近、远期疗效和安全性.方法 将患者随机分为三组,三组患者均口服咪唑斯汀片10 mg,每天1次,连用36天.a组：56例,在口服基础上加用自血治疗,取患者静脉血3 ml立即肌注,隔天1次,共18次;b组：45例,在口服基础上加用卡介菌多糖核酸注射液2ml肌注,隔天1次,连用18次;c组：43例,单纯口服.在治疗结束时和结束后3个月分别进行临床疗效评价和安全性分析.结果 治疗结束时三组的有效率分别为：78.57%、76.74%、55.56%,前两组相比差异无显著性（P〉0.05）,而与c组比较差异均具有显著性（P〈0.05）.治疗结束后3个月,三组的有效率分别变为：80.36%、60.47%、37.78%,差异均具有显著性（P〈0.05）.结论 咪唑斯汀联合自血疗法或卡介菌多糖核酸治疗慢性荨麻疹能提高有效率、降低复发率,前者更优,不良副反应少,值得推广.

Objective To compare the clinical effects of three different methods for chronic urticaria treatment. Methods The chronic urticaria were randomly divided into there groups. The first group astreated with awhole blood 3 ml every two days with intramuscular and mizolastine 10 mg/d for 36 days; the second group as treated with BCG-PSN 2 ml every two days with intramuscular and mizolastine 10 mg/d for 36 days; the third group was treated with mizolastine 10 mg/d only for 36 days. Results The efficient rates of 3 groups were 78.57%,76.74% and 55.56% respectively. There was significant difference in the three groups ,and there was also significant difference in the three groups after the treatment in three months. Conclusion It showed that the treatment of mizolastine and autologous whole blood or BCG-PSN is safe and effective for chronic urticaria which should be extended for application.