感染对重型病毒性肝炎预后的影响

The Effects of Infection on the Prognosis of Severe Hepatitis

目的:探讨感染对重型病毒性肝炎预后的影响。方法:对继发感染的29例重型病毒性肝炎患者及33例无继发感染的重型病毒性肝炎患者进行回顾性分析。结果:继发感染的重型病毒性肝炎患者多器官衰竭的发生率为100％,病死率为79.3％,均明显高于无感染的重型病毒性肝炎患者(P<0.01);PTa、AFP低于无感染的重型病毒性肝炎患者(P<0.01);TBil高于无感染的重型病毒性肝炎患者(P<0.01)。结论:感染加重内毒素血症,进而加剧肝损害及多器官功能衰竭的发生,最终导致病死率增高。

Aim: To probe the effects of infection on the prognosis of severe hepatitis. Methods: 29 cases of severe hepatitis with secondary infection was retrospectively analyzed and compared with 33 cases without secondary infection. Results: The incidence and mortality of multiple organ system failure (MOSF) in patients with infection were 100% and 79. 3% respectively, which were higher than those in patients without secondary infection with great significance (P< 0. 01 ). The PTa and AFP in patients with secondary infection were lower than that in control tgroup as well. while seri-um bilirubin(SB) was higher than that in contral grouop(P<0. 01). Conclusionilnfecton could speed up the endotoximia and then deteriorated the liver damage and MOSF. and finally resulted in high mortality.