癌肿宁对荷肝癌(H_(22))小鼠的抑瘤作用及其对IL-2和NK细胞活性的影响

Effects of Aizhongnimg on Tumor Weight, NKC Activity and IL-2 Activity in Hepatocarcinoma 22-bearing Mice

目的:探讨中药复方癌肿宁治疗实验性肝癌的疗效和机理。方法:建立荷实体型肝癌(H_(22))小鼠模型,观察经癌肿宁治疗对其肿瘤生长、NK细胞活性和IL-2活性的影响。结果:癌肿宁能显著抑制肿瘤的生长,其最高抑瘤率达56.66％,并可明显增强IL-2和NK细胞活性。结论:癌肿宁有明显的抗肝癌作用,并显著提高荷瘤小鼠的抗肿瘤免疫功能。

Aim: To observe the effect and mechanism of the Chinese compound prescription Aizhongning (AZN) on experimental hepatocarcinoma. Methods: The model of hepatocarcinoma 22 solid tumor-bearing mice was produced and treated with AZN. The rate of inhibiting tumor. NKC activity and IL-2 activity were observed. Results: AZN could obviously inhibit the tumor growth, and the highest rate of inhibiting tumor was 56. 66%, Further more, AZN also could significantly promote the NKC activity and the IL-2 activity. Conclusion: AZN had obvious anti-hepatocarcinoma effect and could significantly promote the immunity function of tumor-bearing mice.