摘要
目的:探讨保元强肾Ⅰ号胶囊对慢性肾功能衰竭(CRF中后期尿毒症期)的疗效。方法:40例CRF尿毒症期患者分为2组,均采用低蛋白饮食(LPD)及一般综合治疗(维持水、电解质平衡,纠正心力衰竭和抗感染)。治疗组另加口服保元强肾Ⅰ号胶囊15粒,每日2次,连用60日。对照组加用必需氨基酸(EAA)注射液250ml/d静滴,连用60日。观察用药后肾功能、尿前列腺素和营养状态的改善情况。结果:治疗组总有效率90%,显著优于对照组35%,P<0.01。治疗组治疗后血尿素氮〔BUN,(19.08±3.85)mmol/L〕、血肌酐〔SCr,(383.67±101.17)μmol/L〕均显著低于治疗前〔分别为(30.20±8.92)mmol/L和(582.20±99.27)μmol/L〕和对照组治疗后〔分别为(26.04±7.75)mmol/L和(605.34±170.58)μmol/L〕,P均<0.05;内生肌酐清除率〔CCr,(26.6±9.7)ml·s-1·1.73m-2〕均显著高于治疗前〔(18.8±4.7)ml·s-1·1.73m-2〕和对照组治疗后〔(13.1±6.8)ml·s-1·1.73m-2〕,P均<0.05?
Objective:To investigate the curative efficacy of Baoyuan Qiangshen No.1 Capsule(BYQSC No.1) on moderated and advanced phases (uremia) of chronic renal failure (CRF).Methods:40 cases with CRF (uremia) were randomly divided into 2 groups.Low protein diet (LPD) and conventionally general therapy (keeping fluid and electrolyte balance,correcting heart failure,and antiinfections) were given to both two groups.The BYQSC No.1 15 pills twice a day for 60 days was added to treatment group ( n =20).Otherwise essential amino acids (EAA) injection 250 ml/d infused intravenously for 60 days was added to control group ( n =20).After using drugs the improvements of renal functions,urinary prostaglandins,and nutritional conditions were observed.Results:The total effective rate (90%) in treatment group was significantly superior to that (35%) in control group ( P <0 01).After therapy in treatment group the levels of blood urea nitrogen BUN,(19 08±3 85)mmol/L and serum creatinine SCr,(383 67±101 17)μmol/L were significantly lower than those (30 20±8 92)mmol/L and (582 20±99 27)μmol/L respectively before therapy and were also significantly lower than those (26 04±7 75)mmol/L and (605 34±170 58)μmol/L respectively after therapy in control group (all P <0 05).After therapy in treatment group the creatinine clearance rate CCr,(26 6±9 7)ml·s -1 ·1 73 m -2 was significantly higher than that (18 8±4 7)ml·s -1 ·1 73 m -2 before therapy and also higher than that (13 1±6 8) ml·s -1 ·1 73 m -2 after therapy in control group (all P <0 05).The 6ketoprostaglandin F 1α 6ketoPGF 1α ,(56 04±16 19)ng/L was significantly higher than that (31 53±19 66)ng/L before therapy and also higher than that (18 67±9 08)ng/L after therapy in control group (all P <0 05).The hemoglobin (78 1±13 3)g/L and red blood cell count (3 18±0 51)×10 12 /L were significantly higher than those (69 9±15 4)g/L and (2 26±0 74)×10 12 /L before therapy and also higher than those (58 6±11 8)g/L and (2 01±0 38)×10 12 /L significantly after therapy in control group (all P <0 05).Conclusions:BYQSC No.1 possesses better curative efficacy on moderate and advanced phases of CRF and is superior to treatment with EAA in depressing BUN,SCr,elevating CCr,6ketoPGF 1α ,and correcting anemia.
关键词
肾功能衰竭
慢性
保元强肾
Ⅰ号胶囊
中医药疗法
chronic renal failure\ \ Baoyuan Qiangshen No.1 Capsule\ \ essential amino acid\ \ thromboxin B 2 6ketoprostaglandin F 1α