摘要
目的:探讨人工虫草对慢性肾功能衰竭患者肾功能及免疫功能的影响。方法:53例慢性肾功能衰竭患者随机分为2组,治疗组29例给予人工虫草菌丝粉(金水宝胶囊)及常规西药对症治疗;对照组24例单用相同西药治疗。结果:53例慢性肾功能衰竭患者与健康人比较,单克隆抗体OKT3、OKT4及OKT8均明显降低(P均<0.01)。治疗组治疗后OKT8明显降低(0.14±0.09比0.24±0.10),OKT4/OKT8明显升高(1.97±0.54比1.02±0.48),P均<0.01;对体液免疫无影响。治疗组患者血红蛋白升高〔(78.50±0.53)g/L升至(87.20±0.44)g/L〕,血肌酐明显下降〔(478.5±196.4)μmol/L比(351.7±137.3)μmol/L〕,P均<0.05。结论:人工虫草具有调整慢性肾功能衰竭患者细胞免疫的作用,并能改善肾性贫血及肾功能。
Objective:To investigate the influences of artificial cordyceps sinensis (ACS) on renal functions and immune functions in patients with chronic renal function(CRF).Methods:53 cases with CRF were randomly divided into two groups.The treatment group was treated with hypha powder of ACS i.e Jinshuibao Capsule(金水宝胶囊) and conventional western medicine for relieving symptoms otherwise the control group treated with same western medicine alone.Results:In comparison between 53 cases with CRF and healthy subjects the monoclonal antibodies OKT 3,OKT 4,and OKT 8 in the former were significantly depressed (all P <0 01).After therapy in treatment group the OKT 8 was significantly depressed (0 14±0 09 vs.0 24±0 10),OKT 4/OKT 8 significantly elevated (1 97±0 54 vs.1 02±0 48,all P <0 01).There was not influence on humoural immunities.The hemoglobin was increased (78 50±0 53)g/L vs. (87 20±0 44)g/L and blood creatinine decreased (478 5±196 4)μmol/L vs. (351 7±137 3)μmol/L significantly (all P <0 05).Conclusions:ACS possesses the actions on regulating cell immunities in patients with CRF and is able to improve renal anemia and renal functions.
关键词
肾功能衰竭
慢性
细胞免疫
体液免疫
人工虫草
chronic renal failure\ \ cellular immunity\ \ humoural immunity\ \ artificial cordyceps sinensis\ \ serum creatinine\ \ hemoglobin