盐酸氟西汀与盐酸多塞平对治疗血管性抑郁症的对照研究

A comparative study of fluoxetine and doxepin in the treatment for vascular depression

目的:探讨盐酸氟西汀与盐酸多塞平对治疗血管性抑郁症的疗效和安全性。方法:将70例血管性抑郁症患者随机分为盐酸氟西汀治疗组(35例)和盐酸多塞平治疗组(35例),疗程均为4周,用汉密尔顿抑郁量表(HAMD)和不良反应量表(TESS)分别评定评定疗效及不良反应。结果:治疗4周后,两组抗抑郁疗效显效率分别为85.7%、84.8%,与治疗前比较差异均有统计学意义(P<0.05);两组间HAMD评分比较差异无统计学意义(P>0.05);治疗后第2、4周末两组不良反应比较:盐酸多塞平组明显高于盐酸氟西汀组,比较差异有统计学意义(P<0.05)。结论:盐酸氟西汀和盐酸多塞平改善血管性抑郁患者抑郁症状的疗效相近;用盐酸氟西汀治疗血管性抑郁症的患者,安全性高,依从性好。

Objective To investigate the efficacy and security offiuoxetine and doxepin in the treatment for vascular depression.Methods 70 patients with vascular depression were divided into fluoxetine treatment group（n=35） and doxepin treatment group（n=35） randomly for 4 weeks’respective cure.HAMD and TESS were used to evaluate the efficacy and side effects respectively.Results 4 weeks after treatment,the antidepression efficacy rate of the two groups were 85.7%and 84.8%with great significance compared with those before treatment（P〈0.05） ;intergroup HAMD scores did not show any significance（P〉0.05） ;2 weeks and 4 weeks after treatment,doxepine treatment group had more side effects thanfiuoxetine treatment group with great significace（P〈0.05） .Conclusion The efficacy offiuoxetine and doxepin in the treatment for vascular depression is almost equal,whilefiuoxetine shows higher security and better efficacy.