胆汁CA19-9检测对胆道癌诊断价值的探讨

VALUE OF BILE CA19-9 IN THE DIAGNOSIS OF BILIARY CARCINOMA

目的探讨胆汁ＣＡ１９－９在胆道良恶性病变的诊断价值。方法本研究选择经手术及病理证实的胆道恶性肿瘤２６例，胆道良性病变９２例，正常健康人１３例，采用ＲＩＡ同时联合检测胆汁ＣＡ１９－９、ＣＥＡ，进行定量分析。结果胆汁ＣＡ１９－９的含量分界值为１２０００ｕ／ｍｌ，其敏感性，特异性分别为９２．３１％，７２．８３％；胆汁ＣＥＡ水平分界值为４９０ｎｇ／ｍｌ，其相应指标分别为５７．６９％、７８．２６％。胆汁ＣＡ１９－９、ＣＥＡ含量的假阳性率分别为２７．１７％、２１．７３％。结论胆汁ＣＡ１９－９是诊断胆道癌，判断胆道癌是否被彻底切除，以及监测该病治疗反应有效的肿瘤标志物。

Objective To evaluate the lever of bile CA199 in diagnosing biliary tract carcinoma. Methods We assayed the content of bile CA199CEA in 26 cases with malignant biliary tract neoplasm and 92 cases with benign biliary lesion (BBL)which are all proved both operatively and physiologically,and 13 healthy persons.Radioimmunoassy (RIA) was used to quanititative analyisis the content of CA199 and CEA in bile for patients with benign biliary lesion(BBL) or with biliary tract carinoma(BIC) before and after operation. Results The average content of bile CA199 in BTC,BBL patients and normal persons are 15000u/ml,6000u/ml and 5000u/ml respectively.The dividing value of bile CA199 is 12000u/ml,and its sensitivity,specificity are 92.31% and 72.38% respectively.The dividing value of bile CEA is 490ng/ml,and its corresponding indexes are 57.69% and 78.26%.The FPR(false positive rate)of bile CA199,CEA content are 27.17% and 21.74%. ConclusionZCA199 is a effective tumor marker in diagnosing and indicating operation,Carcinoembryonic antigenas well as supervising the therapeutic feedback about the disease.