亚莫利治疗老年2型糖尿病的临床观察

Clinical Observation on the Efficacy of Glimepiride for the Treatment of Senile Type 2 Diabetic Patients

[目的]探讨格列美脲治疗老年2型糖尿病（T2DM）的疗效及用药安全性.[方法]选取54例老年T2DM患者口服格列美脲（亚莫利）1～4mg/d,总疗程8周,比较治疗前后血脂、糖化血红蛋白、胰岛素抵抗指数、体质量指数、超敏C反应蛋白的变化.[结果]格列美脲治疗后可显著降低血糖、血脂、改善胰岛素抵抗（P〈0.05或P〈0.01）,发生低血糖反应2例（3.7%）.[结论]格列美脲治疗老年T2DM安全、有效,适合作为老年T2DM患者的首选磺脲类降糖药物之一.

[Objective]To study the effect and safety of glimepiride for the treatment of elderly Type 2 diabetic patients. [Methods] Totally 54 elderly patients with Type 2 diabetes mellitus were selected to receive the treatment with oral glimepiride （Yamo Li） 1-4 mg/d for 8 weeks. The changes of blood lipids, glyeosylated hemoglobin （HbA1c）, insulin resistance index, body mass index and SCRP were compared between before and after therapy. [Results] After Glimepiride treatment, blood glucose and blood lipids were decreased significantly, and insulin resistance was improved（ P 〈0.05 or P 〈0.01）. Hypoglycaemic reaction occurred in 2 cases（3. 7%）. [Conclusion] Glimepiride for the treatment of elderly patients with Type 2 diabetes mellitus is safe and effective. Therefore, it is the preferred sulfonylureas for treating elderly patients with Type 2 diabetes mellitus.