芪莲舒痞颗粒对食管黏膜异型上皮样变的逆转作用研究

The reverse action study of Qi Lian Shu Pi to esophageal mucosal alien epithelial appearance

目的探讨芪莲舒痞颗粒对食管黏膜异型上皮样变的逆转作用研究。方法选择山东省消化病防治中心和河南科技大学第三附属医院诊断的食管黏膜异型上皮样变者100例,随机分成两组,一组(治疗组)口服芪莲舒痞颗粒,每次2袋,日3次冲服。对照组口服胃复春片,每次4片,日3次。疗程均为3个月。所有患者在治疗前及疗程结束后2周内作胃镜及病理检查。常规病理对胃黏膜萎缩、肠化、异型增生,按轻、中、重分别记分为1、2、3分,各部位组织得分之和为各项目之总积分。结果比较两组病人治疗前后的胃镜下组织黏膜图像变化,结果发现,芪莲舒痞颗粒与对照组均能明显改善胃镜下组织黏膜的图像,差异均有显著性(P<0.05);比较两组治疗后的胃镜下组织黏膜图像的变化,结果发现,治疗组疗效明显优于对照组(P<0.05)。结论芪莲舒痞颗粒对食管黏膜异型上皮样变有明显的逆转作用,优于既往的常规中药治疗。

Objective To explore the reverse action study of Qi Lian Shu Pi to esophageal mucosal alien epithelial appearance.Methods Randomly selected 100 esophageal mucosal alien epithelial appearance were randomly divided into two groups,experimental groups were given Qi Lian Shu Pi for 3 months by oral,control groups were given Wei FuChun for 3 months.All patients were made gastroscope and pathological examination before therapy and 2 weeks after treatment.Results Qi Lian Shu Pi groups and control groups all can obviously improve the mucous membrane in image changes,The mucous membrane image changes after treatment were significantly better than that before treatment.And The mucous membrane image changes of treatment groups were significantly better than that control groups（P〈0.01）.Conclusion Qi Lian shu Pi have significantly reversal action for esophageal mucosal alien epithelial appearance.