心脏型脂肪酸结合蛋白(H-FABP)在青海地区急诊胸痛患者中应用的疗效评价

Diagnostic Effect of Heart-type Fatty Acid-binding Protein(H-FABP)on Acute Myocardial Infarction in Patients with Emergency Chest Pain in Qinghai Area

目的:观察心脏型脂肪酸结合蛋白(H-FABP)在青海地区急诊胸痛患者中应用的疗效。方法:对2009年1月—2010年6月在我科就诊的98例急诊胸痛患者,在入院<3h内抽取静脉血,进行CK-MB定量、CTnI及H-FABP定性测定,将阳性出现的时间进行比对并作分析。结果:98例急诊胸痛患者,确诊急性心肌梗死(包括ST段抬高型及非ST段抬高型)57例,其他原因胸痛41例(包括心绞痛、胸腔积液、急腹症),急性心肌梗死患者入院后3小时内H-FABP阳性病例为45例,而CTnI为23例,H-FABP阳性率显著高于CTnI,两组相比有统计学差异(P<0.05)。结论:心脏型脂肪酸结合蛋白可以早期确定或排除急性心肌梗死。在急诊室应用中前景广阔。

Objective： To determine the diagnostic evaluation of heart-type fatty acid-binding protein（H-FABP） for acute myocardial infarction（AMI） in patients with emergency chest pain in Qinghai Area.Methods：98 cases of emergent chest pain were collected between January 2009 and June 2010 in the emergency center of our hospital.And all patients underwent the examination of blood level of Creatine kinase（CK-Mb）,cardiac troponin I（CTnI）,and H-FABP in three hours after admission,and a comparison between H-FABP and CK-mb,CTnI was conducted.Results：57 of 98 cases of emergent chest pain had AMI,41 cases had other diseases including angina,pleural effusion and acute abdomen.The positive H-FABP were 45 cases in AMI group and 23 cases in CtnI group respectively,and there was a significant difference in H-FABP（P0.05） between the AMI and CtnI group.Conclusions：Measurement of level of H-FABP contributes to determine the early diagnosis and treatment of AMI in patients with emergency chest pain greatly in Qinghai area.