4Takamatsu Y,Yuki S,Watanabe T.Studies on the concentration of 32 methy 12 121 pheny 1 222 pyrazolin 252 one(MC12186) in MCA occulusion and reperfusion model of rats.Jpn Pharmacol THER,1997,25(suppl):1 785.
6Edaravon A cute Infarction Study G roup E ffect of a novel free radical cavenger edaravone (MCI-186),on acte brain in fraction Randonized,placebo-controlled,double-blind study at multicenters.Corenhvobasc D is.2003,(1 294):15～22.
3Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCJ-186), on acute brain infarction.Randomized, lacebo-controlled, double-blind study at multicenters.Cerebrovasc Dis, 2003, 15: 222 - 229.
4Takamatsu Y, Yuki S, Watanabe T. Studies on the concentration of 3 -methyl-1-1 phenyl-2-pyrazolin-5 -one (MCI-186) in MCA occlusion and reperfusion model of rats. Jpn Pharmacol Ther, 1997, 25(Suppl): S1785 - S1791.
5Jin YJ, Mima T, Raicu V, et al. Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neurosci Res, 2002, 43:75 -79.
6Felberg RA, Burgin WS, Grotta JC. Neuroprotection and the ischemic cascade. CNS Spectrums, 2000, 5:52 -58.
7Takabatake Y, Uno E, Wakamatsu K, et al. The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction. No To Shinkei, 2003, 55:589 -593.
8Tatsushi K, Yasuo K. Mild hypothermia enhances efficacy ofneuroprotective agents in cerebral ischemia in rats. International Congress Series, 2003, 1252:93 - 101.
9Charriaut-Marlangue C, Margaill I, Represa A, et al. Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J Cereb Blood Flow Metab, 1996, 16:186 - 194.
10Li Y, Chopp M, Jiang N, et al. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Met. ab, 1995, 15:389 -397.
