血清CA 125水平与肝硬化Child-pugh分级及腹水量的关系

Relationship of the serum CA 125 of the levels with Child-pugh classification of liver cirrhosis and quantity of ascites

目的探讨肝硬化患者血清肿瘤抗原125(CA 125)水平与肝功能Child-pugh分级及腹水量的关系。方法选肝硬化患者103例(Child-pugh A级36例,B级39例,C级28例;腹水阳性者55例,腹水阴性者48例),正常对照42例,均采用ELISA法检测血清CA 125的水平。结果肝硬化患者血清CA125水平显著高于对照组(P<0.01),其CA 125水平为Child-pugh C级>B级>A级,随着肝损害程度加重呈现进行性升高(P<0.01);肝硬化腹水组及少量腹水组血清CA 125水平均显著高于肝硬化无腹水组(P<0.01),中量腹水组血清CA 125水平显著高于少量腹水组(P<0.01),大量腹水组与中量腹水组的血清CA 125水平比较差异无统计学意义。结论肝硬化患者血清CA 125水平与肝功能损害及腹水程度密切相关,可以被认为是反映肝硬化程度及监测腹水情况的一项敏感指标,对肝硬化腹水的早期诊断及估计预后具有重要的指导意义。

Objective To study the relationship of the levels senun CA 125 with Child-pugh classification of liver cirrhosis and quantity of aseites. Methods A total of 103 patients were studied,including 36 in Child-pugh A, 39 in B ,28 in C. There were 55 patients with aseites and 48 without ascites. The levels of serum CA 125 were measured in all patients and in 42 normal persons by ELISA. Results The levels of serum CA 125 in liver cirrhosis patients were significantly higher than that in eontrols（P 〈0. 01 ）. The results showed the levels of serum CA 125 in Child-pugh C 〉 in B 〉 in A ,increased gradually with aggravating lesion of the liver（ P 〈 0. 01 ）. The levels of serum CA 125 in liver cirrhosis with ascites group and with small amount aseites group were significantly higher than that without aseites group（P 〈0. 01 ）. The levels of serum CA 125 in liver cirrhosis with middle amount aseites group significantly higher than with small amount aseites group（ P 〈 0. 01 ）. There were no statistical significant difference in the levels of serum CA 125 between large amount aseites group and middle amount ascires group. Condusian The levels of serum CA 125 in liver cirrhosis patients have a osculating correlation with lesion of the liver and aseites degree,may serve as a sensitive marker for liver lesion degree and monitoring aseites quantity, and are of value to early diagnosis and estimating prognosis for liver cirrhosis patients with aseites.