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肿瘤-睾丸抗原与肺癌 被引量：1

Cancer-testis antigens and lung cancer
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摘要 肿瘤-睾丸抗原（CTA）在正常睾丸组织的生殖细胞及多种不同组织类型的癌细胞中特异表达.研究证明CTA表达与肺癌的分期、病理类型、复发、转移等密切相关,且在肺癌患者中有抗原性免疫反应.应用CTA对肺癌开展免疫治疗表现出良好的前景. Cancer-testis antigens （CTAs） are protein antigens with normal expression restricted to adult testis and yet are aberrantly activated and expressed in a proportion of various types of tumor tissues. The expressions of CTA correlate with tumor staging, histopathological subtype, recurrence and metastasis in nonsmall cell lung cancer. CTAs are immunogenic in lung cancer patients and have a good prospect in lung cancer Immunotherapy.
作者 徐瑛(综述) 周彩存(审校)
机构地区 同济大学附属上海市肺科医院肿瘤科
出处 《国际肿瘤学杂志》 CAS 2010年第12期916-919,共4页 Journal of International Oncology
关键词 肺肿瘤 抗原 免疫疗法 Lung neoplasms Antigens Immunotherapy
分类号 R735.7 [医药卫生—肿瘤]
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参考文献18

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同被引文献19

  • 1Whitehurst AW. Cause and consequence of cancer/testis antigenactivation in cancer [ J ]. Annu Rev Pharmacol Toxicol, ? 2014 54:251-272.
  • 2Scanlan MJ, Gure AO, Jungbluth AA, et al. Cancer/testis anti gens: an exanding family of targets for cancer immunotherapy[ J~ Immunol Rev, 2002,188:22-32.
  • 3Gjerstorff MF, Pchl M, Olsen KE, et al. Analysis of GAGE, NY- ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma[ J~. BMC Cancer, 2013,13:466.
  • 4Shigematsu Y, Hanagiri T, Shiota H, et al, Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer [ J ]. Lung Cancer, 2010, 68 ( 1 ) : 105-110.
  • 5Tsai JR, Chong IW, Chen YH, et al. Differential expression profile of MAGE family in non-small cell lung cancer[ JJ. Lung Cancer, 2007, 56(2) :185-192.
  • 6Taguchi A, Taylor AD, Rodriguez J, et al. A search for novel cancer/testis antigens inlung cancer identifies VCX/Y genes ex- panding the repertoire of potential immunotherapeutic targets [J~. Cancer Res, 2014,74(17) :4694-4705.
  • 7Tajima K, Obata Y, Tamaki H, et al. Expression of cancer/tes- tis (CT) antigens in lung cancer[ J]. Lung Cancer, 2003,42 ( 1 ) :23-33.
  • 8Greve KB, Pchl M, Olsen KE, et al. SSX2-4 expression in ear- ly-stage non-small cell lung cancer[ J]. Tissue Antigens, 2014, 83 ( 5 ) :344-349.
  • 9Bodey B. Cancer-testis antigens:promosing targets for antigen di- rected antineoplastic immunotherapy [ J 1. Expert Opin Biol T- her, 2002,2(6) :577-584.
  • 10杨丽,王建军,郑英.肿瘤/睾丸基因研究进展[J].医学研究杂志,2008,37(1):13-16. 被引量：1

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国际肿瘤学杂志
2010年 第12期

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