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上皮性卵巢癌组织病理学及分子生物学研究进展 被引量：1

Histopathology and biology of epithelial ovarian cancer
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摘要 上皮性卵巢癌是最为常见的卵巢恶性肿瘤,根据组织病理学特征和分化程度可分为多种亚型.组织学类型和分化程度是决定肿瘤行为及预后的关键因素,了解不同亚型上皮性卵巢癌组织病理学和分子生物学特点,可为选择早期筛查的肿瘤标记物和制订针对性治疗方案提供参考. Ovarian epithelial cancer is the most common type of ovarian cancers. It can be further classified according to the histopathology and cell differentiation of the tumor, which are key factors determining the biologic behavior and prognosis of ovarian epithelial cancer. Understanding the subtype-specific histopathology and molecular biology of ovarian epithelial cancer may provide clues to novel tumor markers for early detection and new therapeutic intervention strategies.
作者 张英丽 羊正炎(综述)
机构地区 浙江省肿瘤医院妇科
出处 《国际肿瘤学杂志》 CAS 2010年第12期942-945,共4页 Journal of International Oncology
关键词 卵巢肿瘤 肿瘤 组织学类型 生物学 Ovarian neoplasms Neoplasms by histologic type Biology
分类号 R737.31 [医药卫生—肿瘤]
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参考文献19

  • 1Malpica A,Deavers MT,Lu K,et al.Grading ovarian serous carcinoma using a two-tier system.Am J Surg Pathol,2004,28(4):496-504.
  • 2Kiechle M,Jacobsen A,Schwarz-Boeger U,et al.Comparative genomic hybridization detects genetic imbalances in primary ovarian carcinomas as correlated with grade of differentiation.Cancer,2001,91(3):534-540.
  • 3Xu X,Weaver Z,Linke SP,et al.Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.Mol Cell,1999,3(3):389-395.
  • 4Yang G,Chang B,Yang F,et al.Aurora kinase a promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.Clin Cancer Res,2010,16(12):3171-3181.
  • 5Lassmann S,Shen Y,Jütting U,et al.Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy.Clin Cancer Res,2007,13 (14):4083-4091.
  • 6Singer G,Oldt R 3rd,Cohen Y,et al.Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma.J Natl Cancer Inst,2003,95(6):484-486.
  • 7Tone AA,Begley H,Sharma M,et al.Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.Clin Cancer Res,2008,14(13):4067-4078.
  • 8Fazili Z,Sun W,Mittelstaedt S,et al.Disabled-2 inactivation is an early step in ovarian tumorigenicity.Oncogene,1999,18(20):3104-3113.
  • 9Landen CN Jr,Birrer MJ,Sood AK.Early events in the pathogenesis of epithelial ovarian cancer.J Clin Oncol,2008,26(6):995-1005.
  • 10Catasus L,Bussaglia E,Rodrguez I,et al.Molecular genetic alterations in endometrioid carcinomas of the ovary:similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas.Hum Pathol,2004,35 (1):1360-1368.

同被引文献4

  • 1Landen CNJr, Birrer MJ, Sood AK. Early events in the pathogenesis ofepithelial ovarian cancer[ J]. J Clin Oncol,2008 ;26(6) :995-1005.
  • 2CottcchiaCM, Curatolo AS, Zurakowski D, et al. Urinary MMP-2 andMMP-9 predict the presence of ovarian cancer in women wity normalCA125 levels[J]. Gynecol Oncol,2011 ; 123(2) :295-300.
  • 3Qie S,SunBC,Zhao XL,ef al. Correlation between expressions of matrixmetalloproteinsse-2 and 9 and vasculogenic mimicry in gastrointestinalstromal tumors[ J). Zhong hua Yi Xue Za Zhi ,2009 ;89( 16) : 1106-9.
  • 4张明明,徐玉清.MMP-2和MMP-9在恶性肿瘤中的研究进展[J].国际肿瘤学杂志,2012,39(11):820-823. 被引量：14

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国际肿瘤学杂志
2010年 第12期

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