支气管哮喘与Toll-样受体的关系研究进展

Exploration of the relation between bronchial asthma and toll-like receptors

支气管哮喘（简称哮喘）是由多种细胞（如嗜酸粒细胞、肥大细胞、淋巴细胞、中性粒细胞、气道上皮细胞等）和细胞组分参与的气道慢性炎症性疾病，是遗传易感个体与各种环境因素共同作用的结果。研究发现，Toll样受体（TLR）和免疫细胞在哮喘的发生发展中起着重要作用。TLR通过识别多种病原体，激活Th1或Th2等免疫反应，被认为是防止或促进哮喘发生一个的重要冈素。本文对TLR及其相关配体在哮喘发病机制中的作刚作以下综述，为哮喘的治疗提供新思路。

The bronchial asthma （asthma） is a chronic inflammatory airway disease characterized by celelular component and infiltration into the airway submucosa of cells, which contain eosinophils, labrocytes, lymphocytes, neutrophils and epitheliums, Asthma is result from the contribution of genetically susceptible individuals and the various environmental stimuli. Studies have examined the contribution of toll like receptors （TLR） and immunocells to the development of asthma. Through identifying the various micro organisms,TLR may be involved in mechanisms provoking Thl or Th2 biased immune responses and may, therefore, be an important factor in either preventing or promoting asthma. This review will explore the relation between TLR and asthma, provide a new idea of therapeutic effect to asthma.