清肺化痰逐瘀汤配合西医治疗慢性阻塞性肺疾病急性加重期30例临床观察

Observation of Qingfei Huatan Zhuyu decoction combined with western medicine on the treatment of acuteexacerbation chronic obstructive pulmonary diseases

目的观察清肺化痰逐瘀汤配合西医治疗慢性阻塞性肺疾病急性加重期痰瘀互结证的临床疗效。方法将慢性阻塞性肺疾病急性加重期痰瘀互结证患者60例随机分为2组。对照组30例单用西药治疗,治疗组30例在对照组治疗基础上加用清肺化痰逐瘀汤口服。2周为1个疗程,1个疗程后统计疗效,并观察2组临床症状、肺功能及血液流变学指标的改变。结果治疗组临床控制率为6.67%,显效率为93.33%,对照组分别为0、70.00%,2组比较均有统计学意义(P<0.01)。2组治疗后咳嗽、喘息、舌下静脉迂曲、气短及颜面口唇紫绀总积分比较差异均有统计学意义(P<0.05,P<0.01),治疗组症状改善优于对照组。2组治疗后肺功能比较差异无统计学意义(P<0.05)。治疗组治疗前后全血黏度、血浆比黏度、纤维蛋白原及红细胞比容比较差异均有统计学意义(P<0.01,P<0.05);对照组治疗前后血浆比黏度、纤维蛋白原差异比较均有统计学意义(P<0.05,P<0.01);2组治疗后全血黏度、纤维蛋白原比较差异均有统计学意义(P<0.01)。结论清肺化痰逐瘀汤可明显减轻慢性阻塞性肺疾病急性加重期患者的临床症状,降低血液流变学中全血黏度、血浆比黏度、纤维蛋白原及红细胞比容,临床疗效显著,无明显不良反应。

objective To observe the effect of Qingfei Huatan Zhuyu decoction combined with western medicine on the treatment of acute exacerbation of chronic obstructive pulmonary diseases（AECOPD） with phlegm stasis syndrome.Methods 60 cases of AECOPD with phlegm stasis syndrome were randomly divided into two groups：30 cases in control group,which were treated by western medicine,30 cases in treatment group which were give Qingfei Huatan Zhuyu decoction combined with western medicine therapy.The course was two weeks.The clinical symptoms,pulmonary function and change of hemorheology were observed after two courses.Results The clinical control rate and excellent rate in treatment group and control group was 6.67%,93.33% and 0,70.00%.There was obvious difference between two groups on the total score of cough,gasp,the vena sublingualis circuity,short breath and cyanotic lips face（P〈0.05）.The improvement of symptoms in treatment group was superior to that in control group（P〈0.05）.There was obvious difference between before and after treatment on whole blood viscosity,plasma specific viscosity,fibrinogen and erythrocrit in treatment group（P〈0.01,P〈0.05）.There was obvious difference between before and after treatment on plasma specific viscosity and fibrinogen in control group（P〈0.01,P〈0.05）.There was obvious difference between two groups on whole blood viscosity and fibrinogen after treatment（P〈0.01）.Conclusion This clinical trial result indicated that Qingfei Huatan Zhuyu decoction may reduce the AECOPD patient＇s clinical symptoms obviously,obviously reduce the whole blood viscosity,the blood plasma specific viscosity,the fibrinogen and erythrocrit.Qingfei Huatan Zhuyu decoction has remarkable clinical curative effect,not obvious untoward effect,is one safety effective medication.