探讨儿童慢性顽固性咳嗽与支原体感染的关系及临床治疗观察

On Relation between Chronic and Persistent Cough of Children and MP Infection and Clinical Observation and Treatment

目的探讨儿童慢性顽固性咳嗽与肺炎支原体（MP）感染的关系及临床疗效观察。方法采用回顾性研究方法对于现将2005年3月至2008年3月在我院的55例确诊慢性顽固性咳嗽患儿，主要表现为肺炎支原体感染为临床特点进行分析，并进一步临床治疗研究。结果①临床特点：在55例确诊慢性咳嗽的患儿中，以慢性顽固性咳嗽为主要症状。58％（32／55）的病例无肺部体征；②外周血：85％（47／55）的病例外周血变化不大，WBC（4—10）×10 9／L之间，嗜酸性粒细胞增多；③特别检查：47．27％（26／55）肺炎支原体IgM（MP—IgM）抗体阳性，83．64％（46／55）PeR技术检测肺炎支原体特异性DNA；④X光报告为多种形式。结论肺炎支原体（MP）感染是引起儿童慢性顽固性咳嗽的病因之一，对儿童慢性咳嗽，特别是顽固性咳嗽的诊治中应更加重视。

Objective To explore the relation between chronic and persistent cough of children and MP infection and clinical observation and treatment. Methods Retrospective Study of the 55 children chronic and persistent cough cases, with a chnical features as pneumonia MP infection, in my hospital from March 2005 to March 2008. Results （1）Clinical Feature：major symptom of these 55 children chronic cough cases is chronic and persistent cough. 58% （32/55）of the cases showed no symptoms in their lungs.（2）Peripheral Blood ：85% （47/55） cases showed no obvious changes in peripheral blood, with their WBC ranging from（ 4 - 10 ）× 10 9/L and their eosinophile granulocyte increased. （3）Special Test：47. 27% （26/55）IgM（MP-IgM）antibody positive, 83.64% （46/55）cased showed pneumonia MP DNA specificity after PcR Test. （4）X-Rate Report：Results varied. Conclusion Pneumonia MP Infection is one of the pathogeny causing chronic and persistent cough of children. Treating the infection is a very important solution in curing chronic and persistent cough of children.