鼻咽部弥漫性大B细胞淋巴瘤临床病理分析

Analysis on the clinicopathology characteristics of diffuse large B-cell lymphoma in asopharyngeal

目的探讨鼻咽部弥漫性大B细胞淋巴瘤（DLBCL）的临床病理特征以提高诊断水平。方法回顾性分析12例鼻咽部DLBCL患者临床病理资料，所有病例均进行CD20、CD3、CD10、BCL6、MUM．1、Ki-67免疫表型测定，部分加做AE1／3、CD30、ALK、CD5和CyclinD1。结果12例鼻咽部DLBCL均为原发，男8例，女4例，年龄34—67岁，平均48岁；5例临床误诊为鼻咽癌。生发中心细胞型7例，活化的B细胞型5例。结论鼻咽部DLBCL极易误诊为鼻咽癌，形态学、免疫表型及临床表现三者结合可确诊。

Objective To investigate the clinicopathology characteristics of asopharyngeal diffuse large B-cell lymphoma（DLBCL） and improve diagnosis of the disease. Methods The clinical, immunophenotypic and histopathologic features of 12 cases asopharyngeal DLBCL were retrospectively studied. The expression of CD20, CD3, CD10, BCL6, MUM-1, Ki-67, CD30, AE1/3, CD30, ALK, CDSand CyclinD1 was detected. Results All patients were primary DLBCL. Among the 12 patients, 8 were males and 4 were femals. The age ranged from 34 to 67 years, average age 48 years old. Among them,7 cases were germinal centre B-cell-like （ GCB）, 5 cases were non-germinal centre B-cell-like（non-GCB）. Conclusion Asopharyngeal DLBCLs are easily misdi- agnosed as carcinomas. The correct diagnosis of DLBCL may be reached by combination of clinic, histological and immunological features.