榄香烯乳注射液联合放疗治疗恶性脑胶质瘤的临床观察

Clinical observation of elemene injection combined with radiotherapy for patients with malignant glioma

目的 探讨榄香烯乳注射液与放疗同步治疗恶性脑胶质瘤的临床疗效.方法 回顾分析我科2004年至2006年恶性脑胶质瘤术后残留或复发的患者34例给予榄香烯乳注射液与放疗同步治疗的临床疗效.放疗采用6MV-X电子直线加速器,DT 50～56Gy,180～200cGy/次,5次/周.榄香烯乳注射液静脉滴注800mg/日,贯穿整个治疗过程,总量为28g.对照组26例单纯放射治疗,治疗方法 同前.结果 （1）观察组获CR 4例,PR 20例,有效率（CR＋PR）为70.6%（24/34）;对照组获CR 2例,PR 11例,有效率（CR＋PR）为50.0%（13/26）,两组差异有统计学意义（P＜0.05）.（2）观察组和对照组1、3年生存率分别为64.7%、41.2%和42.3%、15.4%,两组差异有统计学意义（P＜0.05）.（3）治疗组榄香烯乳注射液副作用主要为发热,发生率为8.8%（3/34）,两组放疗合并轻度脑水肿发生率无显著差异,两组血液学毒性轻微,亦无显著差异.结论 榄香烯乳注射液联合放疗治疗恶性脑胶质瘤术后残留或复发患者的疗效好,生存期延长,毒副反应未见明显增加,值得进一步临床探讨.

Objective To investigate the effect of elemene injection combined with radiotherapy for brain glioma. Methods Form 2004-2006,34 patients with brain glioma had received elemene injection combined with radiotherapy were retrospectively reviewed. According to lesion location, the scope of tumor resection ,these patients received a dose of 50-56Gy/180-200cGy/5 weeks by 6mv-x ray,5 times a week. At the same time, elemene was treated throughout the entire process by 800 mg one day in vein. In control group, 26 patients was treated with radiotherapy alone, and the treatment was the same to the former. Results In the observation group ,4 cases achieved complete response ,20 cases had partial response, the total response rate was 70.6%, while in the control group, 2 cases achieved complete response, 11 cases had partial response, the total response rate was 50. 0% （ P 〈 0. 05 ）. The 1 -, 3-year survival rates were 64. 7% and 41.2% in the observation group and 42. 3% and 15.4% in the control group. The side effect of elemene injection was fever with a rate of 8. 8% ,but the rates of cerebral edema and hematologic toxicity were similar in both groups, Conclusion Elemene injection combined with radiotherapy is effective for brain glioma and has a longer survival time, without increasing the side effects of radiotherapy.