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神经酰胺的凋亡效应在恶性肿瘤治疗中的作用 被引量：3

Apoptotic effect of ceramide on the treatment of malignant tumour
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摘要 神经鞘脂(sphingolipid)是生物膜脂质类的一个家族,它在调节脂质双分子层的流动性和亚结构域方面发挥着重要作用。神经酰胺(ceramide)作为神经鞘脂代谢的核心分子起着第二信使的作用,可介导细胞凋亡、分化、生长抑制等多种生物效应。细胞内神经酰胺浓度降低和恶性肿瘤抗凋亡机制之间的联系越来越密切,因此增加内源性神经酰胺浓度或外源性类似物(模拟神经酰胺活性)可以逆转肿瘤的耐药性,并为恶性肿瘤治疗提供全新方法 。 Sphingolipids are a family of membrane lipids with important structural roles in the regulation of the fluidity and subdomain structure of the lipid bilayer.As a central molecule in sphingolipid metabolism,ceramide induces many biological effects including cell apoptosis,differerentiation and growth inhibition.Attenuation of ceramide levels is increasingly implicated in anti-apoptotic mechanism of malignant tumour,so inducing endogenous ceramide accumulation or mimicking its actions by exogenous ceramide analogue could present a novel therapeutic modality for the treatment of malignant tumour including the reversal of drug resistance.
作者 孙传玉 徐可 夏国伟 丁强
机构地区 复旦大学附属华山医院泌尿外科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2010年第6期734-737,共4页 Fudan University Journal of Medical Sciences
关键词 神经酰胺 恶性肿瘤 凋亡 治疗 ceramide malignant tumour apoptosis therapy
分类号 R73-362 [医药卫生—肿瘤]
  • 相关文献

参考文献31

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二级参考文献35

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共引文献14

同被引文献82

  • 1邹琼宇,邓文龙,蒋舜媛,张磊,彭树林,丁立生.连翘果实中的化学成分研究[J].中国中药杂志,2012,37(1):57-60. 被引量：18
  • 2金道忠,朱兴族.神经酰胺代谢及凋亡信号调节[J].生命科学,2006,18(5):481-486. 被引量：15
  • 3余振喜,王钢力,戴忠,边巴次仁,林瑞超.萝卜秦艽化学成分的研究Ⅱ[J].中国药学杂志,2007,42(17):1295-1298. 被引量：17
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引证文献3

二级引证文献8

复旦学报（医学版）
2010年 第6期

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