维生素D与多囊卵巢综合征相关性的初步研究

Preliminary study on the relationship between vitamin D and polycystic ovary syndrome

目的:研究多囊卵巢综合征(PCOS)患者血清维生素D的浓度与内分泌紊乱的相互关系。方法:收集55例初诊PCOS患者(PCOS组)和20例健康育龄期妇女(对照组),计算体重指数(BMI),测定血清睾酮(T)、雌二醇(E2)、LH、FSH及血清25-(OH)D3浓度,并行OGTT和胰岛素释放试验,计算QUICKI指数。结果:PCOS组25-(OH)D3浓度显著低于对照组(P<0.01)。将PCOS组患者分为肥胖、超重及正常体重者分析,发现肥胖和超重者25-(OH)D3浓度显著低于正常体重者。PCOS组中,25-(OH)D3浓度与BMI、T、LH/FSH呈显著负相关(r=-0.446、-0.390、-0.411,P<0.01),与QUICKI值呈正相关(r=0.423,P<0.01)。结论:维生素D缺乏与PCOS内分泌紊乱密切相关。

Objective：To study the relationship between vitamin D concentration in serum and endocrine disorders in patients with polycystic ovary syndrome（PCOS）.Methods：Fifty-five patients who were newly diagnosed PCOS（PCOS group） and 20 healthy women of reproductive age（control group） were collected.Then to calculate body mass index（BMI） and determine the levels of testosterone,estradiol,LH,FSH and 25-（OH）D3 in serum.OGTT and insulin release test were performed.QUICKI index was calculated.Results：25-（OH） D3 concentration in PCOS group was significantly lower than that in the control group（P0.01）.Subgroup analysis of obese,overweight and normal weight women in PCOS group revealed significantly lower 25-（OH） D3 levels in obese and overweight women.25-（OH）D3 concentration in PCOS group was negatively correlated with BMI,T and LH/FSH（r=-0.446、-0.390、-0.411,P0.01）,but positively correlated with QUICKI index（r=0.423,P0.01）.Conclusion：Hypovitaminosis D was closely related with endocrine disorders in PCOS.