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Fibulin-3与Fibulin-5在盆腔器官脱垂发病机制中的研究进展 被引量：3

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摘要 盆腔器官脱垂(pelvic organ prolapsed,POP)是妇科常见病,严重影响中老年妇女的生活质量和身心健康。其发病率随年龄增长而增加。盆底结缔组织中弹性纤维含量和结构的改变与盆腔器官脱垂的发生密切相关,目前研究认为,抗衰老蛋白Fibulin家族中的Fibulin-3与Fibulin-5在调节细胞外基质中弹性纤维的代谢起重要作用,本文就Fibulin-3与Fibulin-5在弹性纤维的合成及分解代谢中的作用加以阐述,以期了解其在POP发病中的作用。
作者 王睿 杨欣
机构地区 北京大学第一医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2010年第11期857-859,共3页 Progress in Obstetrics and Gynecology
关键词 弹性纤维 Fibulin-3 FIBULIN-5 盆腔器官脱垂
分类号 R711.23 [医药卫生—妇产科学]
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参考文献20

  • 1Hendrix SL, Clark A, Nygaard I, et al. Pelvic organ prolapse in the WomenSs Health Initiative:gravity and gravidity[ J]. Am J Obstet Gynecol,2002,186 : 1160-1166.
  • 2Nakamura T, Ruiz-Lozano P, Lindner V, et al. DANCE, a novel secreted RGD protein expressed in developing, a therosclerotic, and balloon-injured arteries[J]. J Biol Chem, 1999,274 : 22476 -22483.
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二级参考文献8

  • 1Pierce LM, Baumann S, Rankin MR, et al. Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey:a histologic study. Am J Obstet Gynecol, 2007, 197 (1):60-69.
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  • 5Nakamura T, Lozano PR, Ikeda Y, et al. Fibulin-5/ DANCE is essential for elastogenesis in vivo . Nature, 2002, 415 (6868):171-175.
  • 6Kobayashi N, Kostka G, Garbe JH, et al. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem 2007, 282:11805-11816.
  • 7Vukovic J, Ruitenberg MJ, Roet K, et al. The glycoprotein fibulin-3 regulates morphology and motility of ol-factory ensheathing cells in vitro. Glia, 2009, 57 (4) : 424-443.
  • 8McLaughlin PJ, Bakall B, Choi J, et al. Lack of fibulin- 3 causes early aging and herniation, but not macular degeneration in mice. Hum Mol Genet , 2007, 16: 3059- 3070.

共引文献5

同被引文献23

引证文献3

二级引证文献34

现代妇产科进展
2010年 第11期

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