盐城市大气污染物致突变性的研究

A Study on the Mutagenicity of Air Pollutants in Yancheng

用蚕豆叶尖细胞、小鼠骨髓细胞及人淋巴细胞微核试验法监测盐城市大气污染物的致突变活性，结果显示，工业区、商业区、生活区大气存在不同程度的污染（大气污染指数或人受累指数均高于１５），其中工业区污染最严重，最高污染指数为４４８（小鼠微核试验），而教学区无污染（大气污染指数或人受累指数低于１５）。此外，研究中还发现，大气污染物诱发的人淋巴细胞与蚕豆叶尖细胞及小鼠骨髓细胞的微核效应之间均有良好的正相关性（Ｐ＜０００５），并且微核试验用于监测大气污染物的致突变活性比化学监测法更灵敏、更加可行。

The mutagenicit of pollutants in the air in Yancheng was detected by the micronucleus tests in vicia faba leave tip cells,mice bone-marrow cells and human lymphocytes.The results showed that there exist some different levels of pollution in the industrial,commercial,and residential districts,with Atmospheric Pollution Indexes or Individual Damage Indexes all more than 1.5. The air pollution in the industrial district is heaviest with the maximal Air Pollution Index of 4.48(mice bone-marrow micronucleus test).There is no pollution in the teaching area,with Atmospheric Pollution Indexes or Individual Damage Index less than 1.5.In addition,it was found that good direct correlation exist between the human lymphocytes and vicia faba leave tip cells in micronucleus effect and between the human lymphocytes and mice bone-marrow cells in micronucleus effect ( P <0.005).Micronucleus test is also more sensitive and feasible than chemical monitoring for the detection of pollutants in the air.