辛伐他汀治疗儿童肾病综合征高脂血症的疗效观察

Observation on clinical efficacy of simvastatin in treatment of hyperlipoidemia in children with nephrotic syndrome

目的:观察辛伐他汀治疗儿童肾病综合征高脂血症的临床疗效。方法:将肾病综合征患儿55例随机分为治疗组和对照组,其中治疗组30例、对照组25例。对照组给予泼尼松治疗,治疗组在泼尼松治疗的基础上加用辛伐他汀,治疗4周后分别检测两组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)和载脂蛋白B(apoB)水平。结果:治疗组在治疗4周后TC、TG、LDL、apoB水平明显低于对照组(P<0.01)。结论:辛伐他汀治疗儿童肾病综合征高脂血症有较好的临床疗效。

Objective： To observe the clinical efficacy of simvastatin in treatment of hyperlipoidemia in children with nephrotic syndrome. Methods： 55 children with nephrotie syndrome were divided into treatment group （30 cases） and control group （25 cases） randomly, the ehildren in treatment group were treated with simvastatin on the basis of prednisone, the levels of total cholesterol （TC） , triglycefide （TG） , low density lipoprotein cholesterol （LDL） and apolipoprotein B （apoB） in the two groups were deteeted after 4 weeks. Results： The levels of TC, TG, LDL and apoB in treatment group were lower than those in control group after 4 weeks （ P 〈 0. 01 ） . Conclusion ： Simvastatin is effective in treatment of hyperlipoidemia in children with nephrotic syndrome.