金刚烷胺缩3,5-二溴水杨醛Schiff碱的合成、表征及抗菌活性研究

Studies on Synthesis,Characterization and Antibacterial Activity of Schiff base Derived from Adamantaneamine and 3,5-dibromosalicylaldehyde

首先用NaOH的乙醇溶液处理金刚烷胺盐酸盐,得到金刚烷胺.金刚烷胺再与3,5-二溴水杨醛脱水生成金刚烷胺缩3,5-二溴水杨醛Schiff碱(IUPAC命名:N-3,5-二溴亚水杨醛基金刚烷胺,以下简称Schiff碱).Schiff碱用元素分析、红外光谱、核磁共振氢谱等手段进行了表征.测试了四个不同浓度的Schiff碱对金黄色葡萄球菌及大肠杆菌抗菌作用.试验结果表明,当Schiff碱溶液浓度为1.0×10-1mo1.L-1时对金黄色葡萄球菌表现出较强的抑菌作用,当浓度为1.0×10-4mo1.L-1时,表现出较弱的抑菌作用;四个不同浓度Schiff碱对大肠杆菌没有抑菌作用.

Amantadine hydrochloride was first treated with a solution of NaOH in ethanol to give adamantaneamine.Adamantaneamine was further reacted with 3,5-dibromo-salicylaldehyde to lead to N-3,5-dibromo-salicylidene aminoadamantane（Schiff base）.New compound was characterized by elemental analysis,IR and 1H NMR spectroscopy.Antibacterial activity tests against S.aureus and E.coli were conducted with four different concentrations of Schiff base.The result showed that the Schiff base solution performed a strong active against S.aureus at 1.0×10-1 mo1·L-1 in DMF,and a weak inhibition performance at 1.0×10-4mo1·L-1.The Schiff base solutions with four different concentrations performed no inhibitory effect against E.coli.