磷酸丙泊酸钠与镇静

Fospropofol Disodium and Sedation

磷酸丙泊酸钠（磷酸丙泊酸，fospropofot disodium，FPD）为新型镇静／催眠药，是一种水溶剂型的丙泊酚前体药，在体内通过代谢释放出活性的丙泊酚（f）发挥镇静效应。由于FPD在体内的水解过程．其药物动力学和药效学特性较脂肪乳剂型的丙泊酚有显著差异。已有的临床实验证实，FPD可安全有效的用于结肠镜、纤维支气管镜及小手术病人的镇静。随着研究的进一步进展，磷酸丙泊酸钠将有更为广阔的临床应用前景。

Fospropofol disodium（Fospropofol）,a sedative/hypnotic drug,is a water-soluble prodrug of propofol,metabolized in vivo to produce liberated active propofol which performs sedative function.As its hydrolytic action in vivo,the pharmacokinetics and pharmacodynamics of fospropofol disodium are significantly differ from lipid-emulsion-based propofol. Clinical trials of fospropofol disodium can be safe and effective for the sedation of colonoscopy, flexible bronchoscopy and minor procedures. With further progress, fospropofol disodium will have a broader clinical application.