异维A酸红霉素凝胶与0.1%他扎罗汀乳膏治疗120例痤疮临床疗效观察

Observation of clinical effect of isotretinoin erythromycin gel and 0.1% tazarotene cream treatment for 120 cases of acne

目的评价异维A酸红霉素凝胶治疗寻常痤疮的疗效及安全性。方法将120例寻常痤疮患者随机分为治疗组和对照组,各60例。治疗组用异维A酸红霉素凝胶治疗,对照组用1%他扎罗汀乳膏治疗。8周时观察各组皮损变化情况。结果疗程结束时治疗组有效率为88.3%;对照组有效率为73.3%,P<0.05;治疗组皮损总数少于对照组,差异有统计学意义(P<0.05);治疗组与对照组不良反应分别为5例(8.33%)、26例(46.3%),P<0.05。结论异维A酸红霉素凝胶治疗痤疮效果优于他扎罗汀乳膏,且更安全。

Objective To evaluate the efficacy and safety of isotretinoin and erythromycin gel in the treatment of acne vulgaris.Methods A total of 120 patients with acne vulgaris were randomized to receive either isotretinoin gel and 0.1% tazarotene cream（used as control）.The changes in lesion were observed after 8 weeks of treatment.Results In the experimental group,the total effective rate was 88.3 %.In the control group,the total effective rate was 73.3 %.There was statistical difference between the 2 groups,P〈0.05.In the experimental group,mean of lesions was 10.03±5.19,while in the control group is 13.85±6.25.There was statistical difference between the 2 groups（P〈0.05）.The adverse reaction was 8.33% in the experimental group and 46.3% in the control group respectively.There was a significant difference between two group（P〈0.05）.Conclusion Isotretinoin and erythromycin gel is more safe and more effective than 0.1% tazarotene cream in the treatment of acne vulgaris.