R-CHOP方案初治B细胞非霍奇金淋巴瘤34例临床分析

Clinical analysis of initial CHOP regimen treatment for 34 cases of B cell non-Hodgkin lymphoma

目的观察R-CHOP方案治疗初治B细胞非霍奇金淋巴瘤(NHL)的疗效、安全性及不良反应。方法回顾性分析2003年1月至2008年1月采用R-CHOP方案治疗34例初治B细胞NHL的疗效、安全性及不良反应。结果 CR21例(61.8%),PR 10例(29.4%),CR+PR 31例(91.2%),SD 1例,PD 2例。结论 R-CHOP方案治疗初治B细胞NHL疗效显著,效价比高,不良反应小,耐受好。

Objective To evaluate the efficacy of R-CHOP therapy in previously untreated patients with B cell non-Hodgkin lymphoma（NHL）,and observe the adverse events.Methods we have retrospectively analysed the efficacy and adverse events with R-CHOP in 34 previously untreated patients with B-cell NHL between January 2003 and January 2008.Results There were twenty one patients CR（61.8%）,ten PR（29.4%）,one SD and two PD,for an overall response rate of 91.2%.Conclusion R-CHOP chemotherapy was effective,pharmaco-economically beneficial and well tolerated in previously untreated patients with B-cell NHL.