舒血宁注射液联用半夏白术天麻汤加减治疗椎-基底动脉供血不足38例

Shuxuening Injection With Banxia Baizhu Tianma Decoction Treatment Vertebral-Basilar Insufficiency of 38 Cases

[目的]观察舒血宁注射液联用半夏白术天麻汤加减治疗椎-基底动脉供血不足(VBI)的疗效以及治疗前后脑血流动力学及血液流变学变化。[方法]将68例椎-基底动脉供血不足患者随机分为两组,治疗组38例用舒血宁注射液20mL/次联用半夏白术天麻汤加减治疗;对照组30例用舒血宁注射液20m[/次治疗,1次/d,14d为1疗程。所有病例均于治疗前后观察患者症状、血液流变学及经颅多普勒超声(TCD)的变化。[结果]治疗组及对照组治疗前血液流变学及双侧椎动脉、基底动脉的平均血流速度(Vm)均表现为不同程度的异常,治疗后两组患者症状、血液流变学各项指标及双侧推动脉、基底动脉的Vm值明显改善,治疗组与对照组相比较改善更为明显(P<0.05)。[结论]舒血宁联用半夏白术天麻汤加减可明显改善椎-基底动脉供血不足患者的症状、血液流变及TCD指标异常,具有扩张血管、解除血管痉挛,增加椎-基底动脉血流量等作用。

[ Objectlve]To observe Shuxuening Injection with Banxia Baizhu Tianma decoction treating Vertebral -basilar artery insufficiency （VBI） and the efficacy of cerebral hemodynamics before and after treatment and blood theology changes. [ Method] 68 cases of vertebral - basilar artery insufficiency were randomly divided into 2 groups, treatment group, 38 cases with Shuxuening injection 20mL / times associated with Banxia Baizhu Tianma decoction ; the control group of 30 patients with Shuxuening injection 20mL / second treatment, 1 / d, 14d to a course of treatment. All patients were observed before and after treatment in patients with symptoms, blood rheology and transcranial Doppler ultrasound （ TCD ） changes. [ Results ] treatment group and control group before treatment hemorheology and bilateral vertebral arteries, basilar artery mean flow velocity （Vm） showed different degrees of abnormal symptoms after treatment, blood rheology indicators and bilateral vertebral arteries, basilar artery of Vm was significantly improved in the treatment group compared with the control group improved more significantly （ P 〈 0. 05 ）. [ Conclusion ] Shuxuening combined with Banxia Baizhu Tianma decoction can improve the vertebral - basilar artery insufficiency symptoms, indicators of abnormal blood rheology and TCD, with the expansion of blood vessels, relieve spasm, increase vertebral - basilar artery flow such as role.