70例脐部分泌物细菌学分析

Pathogenic Analysis of Neonate Navel Infection

目的了解新生儿脐部感染病原菌分布和药物敏感率,为临床合理选择抗菌药物治疗新生儿脐炎提供依据。方法 2008年12月-2009年11月医院收治的新生儿脐部感染患者70例,进行脐部分泌物细菌培养和药敏试验,对所获得的67株病原菌的种类及药敏进行分析。结果 70例中共分离出病原菌67株,主要病原菌为革兰阳性球菌,占55.2%,其中以金黄色葡萄球菌占比例较高(26.9%);革兰阴性杆菌占44.8%,以大肠埃希菌占比例较高(22.4%);革兰阳性球菌对米诺环素、替考拉宁、万古霉素等敏感率较高,革兰阴性杆菌对亚胺培南、三代头孢、头孢吡肟、阿莫西林/克拉维酸等敏感率较高。结论分析新生儿脐部感染的病原菌及耐药状况,对临床诊断和治疗具有重要作用。

OBJECTIVE To investigate the distribution of pathogens of neonate navel infection and their drug sensitivity to antibiotics,and to provide basis to choose rational antibiotics for clinical treatment of neonatal omphalitis.METHODS Bacteria culture and antibiotic sensitivity test were undertakenfor infected navel secretion of 70 newborn cases selected from Dec 2008 to Nov 2009 were conducted,the category and antibiotic sensitivity of the obtained 67 pathogens were analyzed.RESULTS Among the 70 cases,67 pathogens were isolated.The main pathogens were Gram-positive cocci,accounted for 55.2%,the most of which were S.aureus（26.9%）.The Gram-negative bacilli took up 44.8%,among which Escherichia coli accounted for（22.4%）.The Gram-positive cocci were sensitive to minocycline,teicoplanin and vancomycin.The Gram-negative bacilli were highly sensitive to imipenem,the third generation cephalosporins,cefepime and amoxicillin/clavulanic acid.CONCLUSION Analyzing the pathogens of navel infection of neonate and the drug resistance to antibiotics is important to clinical diagnosis and treatment.