嘉兴地区住院婴幼儿感染人偏肺病毒的研究

Human Metapneumovirus Infection of Hospitalized Infants in Jiaxing District

目的了解人偏肺病毒(hMPV)和合胞病毒(RSV)在嘉兴地区的流行情况及感染的人群分布。方法收集医院2008年12月-2009年12月因急性呼吸道感染入院治疗的患儿共计3359例,用实时定量PCR和直接免疫荧光(DFA)法对样本进行检测。结果 3359例样本中hMPV阳性63例,RSV阳性494例,在整个季节中hMPV的阳性率为1.88%,RSV为14.7%;流行季节hMPV最高感染率为6.14%,RSV为41.15%;感染的人群中<6月龄婴幼儿的患病率最高,其hMPV的感染率为2.71%,RSV为24.69%。结论 hMPV和RSV在嘉兴地区按一定的时段流行,并且易感<6月龄的婴幼儿。

OBJECTIVE To understand the epidemics and the infected population distribution of human metapneumovirus（hMPV） and respiratory syncytial virus（RSV） in Jiaxing destrict.METHODS A total of 3359 cases of children with acute respiratory infection in hospital were collected from Dec 2008 to Dec 2009,and their samples were inspected through real-time quantitative polymerase chain reaction（Q-RT-PCR） and direct immunofluorescence（DFA）.RESULTS There were 63 cases infected hMPV and 494 cases infected RSV among 3359 case samples.The infection rate of hMPV was 1.88%,and that of RSV was 14.7% in all seasons.The highest infection rate of hMPV was 6.14%,and that of RSV was 41.15% in prevalent season.The infants with less than six months were the highest infection population,and their infection rate of hMPV was 2.71%,and that of RSV was 24.69%.CONCLUSION The infection trend of hMPV and RSV is timely prevalent in Jiaxing district and these infants with less than six months are susceptible to hMPV and RSV.