替考拉宁治疗老年下呼吸道感染患者疗效分析

Teicoplanin in Treatment for Senile Patients with Lower Respiratory Tract Infection:Clinical Effect Analysis

目的评价替考拉宁治疗老年下呼吸道感染患者的临床疗效及安全性。方法选择老年下呼吸道感染患者共40例,单盲、完全随机分为对照组和治疗组各20例;治疗组选用替考拉宁注射液0.4 g/d,静脉滴注,疗程7~14 d;对照组选用盐酸去甲万古霉素注射液0.4 g,静脉滴注,2次/d,疗程7~14 d。结果对照组、治疗组有效率分别为65.0%、90.0%,差异有统计学意义（P〈0.05）;细菌阴转率分别为80.0%、85.5%,差异无统计学意义;不良反应发生率分别为40.0%、15.0%,差异有统计学意义（P〈0.05）。结论替考拉宁是治疗老年下呼吸道感染患者的较为安全有效的药物。

OBJECTIVE To evaluate the clinical effect and safety of teicoplanin in treatment for the elderly patients with lower respiratory tract infection.METHODS A total of 40 elderly patients with lower respiratory tract infection were randomly divided into control group（0.4 g/d norvancomycin,ivdrip,course of treatment 7～14 d） and treatment group（0.4 g/d teicoplanin,ivdrip,twice a day,course of treatment 7～14 d）.RESULTS The clinical effective rates in control group and treatment group were 65.0% and 90.0%,respectively,the difference was statistically significant（P0.05）,while the bacterial clearance rates were 80.0% and 85.5%（P0.05）.The incidence rates of the adverse reactions were 40.0% and 15.0%,respectively（P0.05）.CONCLUSION Teicoplanin is an effective and safe drug in treatment of lower respiratory tract infection in elderly patients.