艾迪注射液配合化疗对恶性肿瘤患者医院感染的影响

Effect of Aidi Injection Combined with Chemotherapy on Nosocomial Infection of Patients with Malignant Tumor

目的探讨中药制剂艾迪注射液配合化疗对恶性肿瘤患者医院感染的影响。方法 166例恶性肿瘤患者分为单纯化疗组和联合化疗组,均给予吉西他滨奥沙利铂(GEMOX)方案常规化疗,联合化疗组加用艾迪注射液100 ml+生理盐水400 ml,静脉滴注。结果联合放疗组总有效率为52.2%,高于单纯放疗组的36.1%,差异有统计学意义(P<0.05);两组患者医院感染率分别为17.4%和34.0%,差异有统计学意义(P<0.05);以呼吸道感染最严重,其次为胃肠道和泌尿道;联合化疗组的CD3+、CD4+、CD8+和CD4+/CD8+均有不同程度的改善,与对照组比较,差异有统计学意义(P<0.05);联合化疗组骨髓抑制率为14.5%,显著高于单纯化疗组的25.8%,两组比较,差异有统计学意义(P<0.05)。结论艾迪注射液配合化疗能增强恶性肿瘤患者的免疫功能,减少化疗带来的不良反应,降低医院感染发生率。

OBJECTIVE To explore the effect of Aidi injection a chinese herd preparation,combined with chemotherapy on nosocomial infection of patients with malignant tumor.METHODS Totally 166 cases were divided into two groups and they were all treated with GEMOX therapy.The combination chemotherapy group was given Aidi injection 100 ml ＋ saline 400 ml additionally,intravenous drip,and the other group was given chemotherapy alone.RESULTS The overall response rate was 52.2% in combination chemotherapy group,higher than that of 36.1% in single chemotherapy（P0.05）.The two groups also produced significant difference in nosocomial infectious rate（17.4% vs 34.0%,P0.05）.The major infection sites were respiratory tract,gastrointestinal tract and urinary tract.CD3＋,CD4＋,CD8＋ and CD4＋/CD8＋ in combination chemotherapy group were all shown some improvement,compared with single chemotherapy,the difference was statistically significant（P0.05）.The suppressive rates of bone marrow were 14.5% and 25.8% in the two groups.CONCLUSION Aidi injection combined with chemotherapy can enhance the immune function of patients with malignant tumors,decrease the toxicity caused by chemotherapy and reduce the incidence of nosocomial infection.