967例泌尿生殖道支原体药敏试验结果分析

Drug Sensitivity of Mycoplasma Isolated from Genitourinary Tract in 967 Cases

目的了解泌尿生殖道支原体感染的现状及耐药性,为临床合理用药提供依据。方法采用法国生物梅里埃公司支原体IST试剂盒,对泌尿生殖道标本进行支原体培养及药敏试验。结果 2818例疑似非淋菌性尿道炎(NGU)患者中检出967例支原体培养阳性,阳性率为34.3%,其中解脲脲支原体(Uu)阳性778例(27.6%),人支原体(Mh)阳性30例(1.1%),Uu和Mh混合阳性159例(5.6%),女性标本阳性率为45.3%,而男性阳性率为29.9%,两者差异有统计学意义(P<0.01);支原体对普那霉素、交沙霉素、多西环素、四环素的耐药率较低,分别为5.1%、5.3%、6.5%、14.5%。结论泌尿生殖道支原体感染主要以Uu发病率最高,人支原体不多见;治疗支原体感染的首选抗菌药物为交沙霉素、多西环素。

OBJECTIVE To investigate the infection status and drug resistance of Mycoplasma strains isolated from genitourinary tract and provide strategies for the reasonable medication in clinics.METHODS A total of 2818 urogenital specimens were cultured for Uu,Mh and the drug sensitivity was performed by using Mycoplasma IST kit.RESULTS Totally 967 strains of mycoplasma were detected positive with the positive rate of 34.3%.The positive cases of Uu,Mh and Uu mixedwith Mh were respectively 778（27.6%）,30（1.1%） and 159（5.6%）.The positive rate of mycoplasma in males was 29.9% while in females was 45.3%,which difference was statistically significant（P0.01）.The result of drug sensitivity test showed that the drug resistant rates of mycoplasma to PRI,JOS,DOX and TET were lower with the drug resistant rates of 5.1%,5.3%,6.5% and 14.5%,respectively.CONCLUSION Mycoplasma infection in genitourinary tract is mainly due to Uu infection.Mh is not very common.Josamycin and deoxycydine are the first choices for the treatment of mycoplasmas infection.