非淋菌性尿道炎患者支原体感染及药敏分析

Mycoplasma Infection and Drug Susceptivity in Outpatients with Nongonococcal Urethritis

目的了解非淋菌性尿道(宫颈)炎(NGU)患者支原体感染状况及对抗菌药物的敏感性,为临床合理使用抗菌药物提供参考。方法采用支原体培养、鉴定、药敏一体化试剂盒对2159例疑似NGU患者进行支原体培养,并对阳性标本进行药敏试验。结果 2159例NGU患者支原体培养阳性1212例,支原体感染率为56.2%;其中解脲脲支原体(Uu)、人支原体(Mh)及Uu+Mh混合感染的阳性率分别为38.0%、2.6%、15.6%;支原体对所用抗菌药物敏感性较强的依次为普那霉素、多西环素和四环素,而对环丙沙星和氧氟沙星有较高的耐药性。结论 NGU患者支原体感染率较高,以Uu感染为主;目前治疗NGU支原体感染的首选抗菌药物为普那霉素、多西环素或四环素。

OBJECTIVE To investigate the infection and drug resistance of mycoplasma in outpatients with nongonococcal urethritis（NGU）,to provide bases for the rational application of antibiotics.METHODS Mycoplasma IST2 kits were used to isolate mycoplasma and drug susceptibility was detected with mycoplasma positive specimens.RESULTS Form 2159 specimens 1212 were positive for mycoplasma,the positive rate was 56.2%.The positive rate of Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） were 38.0% and 2.6%,respectively,and the mixed infection rate was 15.6%.Among 9 commonly employed antibiotics,Mycoplasma were susceptible to pristinamycin,doxycycline and tetracycline in turn,and severely resistant to ciprofloxacin and ofloxacin.CONCLUSION Mycoplasma（especially Uu） are the main pathogens of NGU.It is important to isolate mycoplasma and test their drug susceptibility with NGU patients.Pristinamycin,doxycycline and tetracycline are the first choice for the NGU patients in this area.