肾功能不全患者替考拉宁药物浓度监测的研究进展

Advances in therapeutic drug monitoring of teicoplanin for the patients with renal insufficiency

替考拉宁是临床治疗重症革兰阳性菌感染的有效药物,其治疗效果和血药浓度密切相关,而肾功能不全患者对替考拉宁的清除和其肌酐清除率与采用的血液净化方式密切相关,因此对于上述患者需要进行治疗药物浓度监测,协助个体化用药。本文就不同血液净化方式下替考拉宁的药物浓度监测结果及给药方案进行综述,以期为其在临床的合理用药提供参考。

Teicoplanin has long been considered the good standard for treatment life-threatening Gram-positive bacterial infection.It is generally accepted that the effect of teicoplanin is closely related to the serum trough level,however for the patients with renal insufficiency,the clearance of teicoplanin is closely related to the creatinine clearance rate and the method of blood purification,Therefore,physicians should use therapeutic drug monitoring（TDM） to regulate the dose of teicoplanin,achieve the goal of individual administration regimen for those patients.In this paper,the administration regimen of teicoplanin and the TDM results of patients who received different methods of blood purification were reviewed,in order to help physicians to use teicoplanin more reasonable.