幽门螺杆菌感染与反流性食管炎关系的meta分析

A Meta-analysis on the Association between Helicobacter Pylori Infection and Reflux Esophagitis

本文采用Meta分析方法对国内已发表的有关幽门螺杆菌(Hp)感染与反流性食管炎关系的研究进行综合评价.通过检索电子数据库、手工检索相关期刊与书籍、检索互联网,并通过查找参考文献和引文进行了全面的文献检索;使用自行设计的表格提取了有关的数据;对各纳入研究利用Review Manager4.2软件进行meta分析.本文研究共纳入文献24篇,经Meta分析,反流性食管炎组共5026例,Hp感染率约为43.67%,对照组共4442例,感染率高于反流性食管炎组约为57.23%,合并OR值为0.48(95%CI:0.39-0.59).经几何漏斗图和失效安全数分析结果显示,发表偏倚对研究结果影响较小.敏感性分析表研究明结果稳定可靠.从而证实幽门螺杆菌感染在反流性食管炎的发病中能够起到保护作用.

Analyzing all the studies that have been published in china to evaluate the relationship between Helicobacter pylori infection and reflux esophagitis by means of Meta analysis.Methods： Searching electronic database;Searching journals and books by hand;Searching the internet and citations;Combinations of Medical Subject Headings were used in the computer searches,including Helicobacter-pylori,Helicobacter infections and reflux esophagitis;Using self-designed forms to extracte the relevant data;To analyze the references consistent with inclusion criteria by reviewing manager 4.2,calculating the odds ratio and 95% confidence interval,then drawing funnel plot.Results： 24 articles have been included in this review.The relationship between reflux esophagitis and Helicobacter pylori infection were analyzed by means of random effect model of meta-analysis.The ratio of the Hp infection found in the patients with RE was 43.67%,which was lower than the ratio of the controls 57.23%.The incorporated OR was 0.48,and 95% CI was 0.39 ～ 0.59.The results are stable and reliable by sensitivity analysis.Conclusions： Helicobacter pylori may plays a protective role in episode procedure of reflux esophagitis.