血清肝细胞生长因子与高血压患者合并急性冠脉综合征的相关性

Hepatocyte growth factor in patients with hypertension combined with acute coronary syndrome

目的 探讨肝细胞生长因子（HGF）在原发性高血压及急性冠脉综合征（ACS）患者血清中的表达水平及其临床意义.方法 采用双抗体夹心酶联免疫荧光吸附法（ELISE）测定25例单纯高血压患者、20例高血压合并不稳定型心绞痛（UA）患者、25例高血压合并急性心肌梗死（AMI）患者、25名健康者的HGF血清浓度.结果 单纯高血压组、高血压合并UA组和高血压合并AMI组血清HGF浓度较正常对照组明显高,差异有统计学意义（P＜0.01）;高血压合并UA组、高血压合并AMI组血清HGF浓度较单纯高血压组明显高,差异有统计学意义（P＜0.05）;高血压合并AMI组血清HGF浓度较高血压合并UA组明显高,差异有统计学意义（P＜0.05）.结论 高浓度的HGF与血管内皮损伤和修复以及不稳定的粥样斑块破裂有关.测定HGF浓度将成为早期诊断高血压及其分级的重要指标和早期筛查不稳定冠状动脉粥样硬化斑块的新手段.

Objective To observe the serum level of hepatocyte growth factor （HGF） and its clinical significance in primary hypertension and acute coronary syndrome. Methods The levels of serum HGF was measured in 25 simple hypertensive patients, 20 UA and hypertensive patients, 25 AMI and hypertensive patients and 25 normal subjects by using solid-phase double-antibody sandwich enzyme linked immunosorbent assay （ELISA）. Results The serum levels of HGF on admission were significantly increased in simple hypertensive,with UA,with AMI patients compared with normal subjects （P〈0.01）. There were significant differences between UA and hyper- tensive patients ,AMI and hypertensive patients and simple hypertensive patients（P〈0.05）. A significant differences were obviously between AMI and hypertensive patients and UA and hypertensive patients （P〈0.05）. Conclusion High serum concentration of HGF is related to repair endothelial cell injury and rupure of unstable atherosclerotie score. Serum HGF levels may provide a serological mark for the diagnosis and grade of hypertension and a new marker for early unstable coronary atherosclerotie score.