糖调节受损者血清炎症细胞因子表达水平的研究

Research of Serum Inflammatory Cytokines Expression Level on Patients who Impaired Glucose Regulation

目的探讨糖调节受损(IGR)人群外周血炎症细胞因子表达水平与正常糖耐量(NGT)人群的差异。方法按照WHO糖尿病诊断标准,随机选择IGR者172例,NGT者168例,2型糖尿病(T2DM)者106例,采集外周血分别测定外周血白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-(TNF-)、超敏C-反应蛋白(hs-CRP)的水平,并与其它临床资料进行综合比较。结果 IGR组IL-1βI、L-6、TNF-、hs-CRP水平显著高于NGT组但低于T2DM组(P<0.05或P<0.01)。结论 IGR发生发展过程中伴有炎性反应,检测炎症细胞因子对评价IGR人群具有一定的预测作用。

Objective To approach the difference in patients between IGR’s inflammatory cytokines expression level in peripheral blood and NGT.Methods According to WHO diabetes melli-tus’ diagnostic criteria,randomly choosing 172 patients with IGR,168 with NGT,106 with T2DM,collecting peripheral blood to determine the IL-1βI、L-6、TNF-and hs-CRP,and then compared with other clinical materials comprehensively.Results IL-1βI、L-6、TNF-and hs-CRP in the group of IGR are much higher than the group of NGT,but lower than the group of T2DM（P 〈0.05 or P 〈 0.01）.Conclusion Associated with the development and progression of inflammatory response,detection of inflammatory cytokines have a certain prediction on the evaluation of IGR patients.