检测脂联素、IGF-1在子宫内膜异位症血清中的水平及与体重指数的相关性研究

Study of Level of Adiponectin ZGF-1 in Endometriosis Serum and Its Relationship with BMI

目的检测子宫内膜异位症血清中脂联素(adiponectin,APN),胰岛素样生长因子-1(IGF-1)的水平及与体重指数(BMI)的相关性。方法应用双抗夹心ELISA法测定40例内膜异位症患者和30例其他妇科良性疾病患者及30例健康体检者的血清APNI,GF-1的水平,并计算所有实验者的BMI。结果内异症患者血清APN水平明显低于对照组(P<0.05)I,GF-1水平高于对照组(P<0.05),内膜异位症患者体重指数低于对照组(P<0.05),而两对照组间无差异(P>0.05)。内膜异位症体重指数与血清脂联素水平呈正相关(r=0.891,P<0.05),而与IGF-1水平呈负相关(r=-0.672,P<0.05)。结论 APNI,GF-1可能参与内膜异位症的发生发展,APN在内膜异位症发展过程中起对抗作用,而IGF-1对内膜异位症维持及发展起促进作用。内膜异位症患者具有较低体重指数,可能是其特有体征之一,其发生机制可能与APNI、GF-1水平变化有关。

Objective To detect the serum level of adiponectin and IGF-1 in endometriosis and inpendence with BMI.Methods Serum level of adiponectin and IGF-1 were measured with ELISA in 40 patients with endometriosis and 60 controlst,herefore compute the BMI of all the experi-ments.Results The level of APN in serum in endometriosis group were significantly lowert,hus IGF-1 were significantly higher than those in the controls（P 〈 0.05）,have no difference between the two controls（P 〉 0.05）,the BMI of the patients with endometriosis were significantly lower than those of the two controls（P 〈0.05）,have no difference between the controls.Conclusion It is likely that APN and IGF-1 may play a role in the pathogenesis of endometriosis,APN withstand the develop of endometriosis,but IGF-1 promote it’s developet,he patients with endometriosis have low BMII,t is a possible particular sign of endometriosis.